Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566956 | 1.00 | MAPT (0.49) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL8566960 | 1.00 | MAPT (0.49) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL27693463 | 0.82 | MAPT (0.46) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL16135451 | 0.82 | MAPT (0.46) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL17248041 | 0.79 | MAPT (0.54) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL10528568 | 0.78 | ALDH1A1 (0.58) | MAPTALDH1A1KMT2AGAAPOLB | |
| SCHEMBL8567784 | 0.77 | MTNR1A (0.49) | MAPTALDH1A1KMT2A | |
| SCHEMBL431522 | 0.77 | MTNR1A (0.49) | MAPTALDH1A1KMT2A | |
| SCHEMBL8567787 | 0.77 | MTNR1A (0.49) | MAPTALDH1A1KMT2A | |
| SCHEMBL30576465 | 0.77 | MTNR1A (0.49) | MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |