Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565253 | 0.83 | NQO1 (0.50) | NCF1NQO1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8559644 | 0.79 | MAPT (0.53) | APPPOLBSMN1; SMN2MEN1LMNA | |
| SCHEMBL5188214 | 0.77 | POLB (0.59) | NCF1NQO1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL15663471 | 0.75 | KDM4E (0.49) | ALDH1A1POLBSMN1; SMN2MEN1NPC1 | |
| SCHEMBL27200601 | 0.75 | MAPT (0.49) | APPALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL3364517 | 0.74 | NCF1 (0.65) | NCF1APPNQO1ALDH1A1POLB | |
| SCHEMBL3389504 | 0.73 | KDM1A (0.53) | NCF1ALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL1598487 | 0.73 | NCF1 (1.00) | NCF1NQO1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5786907 | 0.72 | TDP1 (0.73) | APPALDH1A1SMN1; SMN2MEN1NPC1 | |
| Hydrochloric Acid SCHEMBL27898424 | 0.72 | NCF1 (0.96) | NCF1NQO1ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |