Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.42 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559109 | 0.81 | HTR3A (0.37) | MAPTBACE1TP53SMN1; SMN2CTSD | |
| SCHEMBL27200601 | 0.79 | MAPT (0.49) | MAPTPDE7AAPPBACE1CYP3A4 | |
| SCHEMBL8567023 | 0.79 | NCF1 (0.56) | MAPTAPPCYP3A4MAPK1TP53 | |
| SCHEMBL11193963 | 0.78 | MAPT (0.50) | MAPTPDE7APDE7BAPPCYP3A4 | |
| SCHEMBL3389504 | 0.78 | KDM1A (0.53) | MAPTBACE1CYP3A4TSHRMAPK1 | |
| SCHEMBL11056189 | 0.73 | LMNA (0.67) | MAPTAPPBACE1PLAUTP53 | |
| SCHEMBL2130719 | 0.71 | BACE1 (0.72) | BACE1PLAUPIK3CG | |
| SCHEMBL23457529 | 0.71 | HTR3A (0.35) | BACE1SMN1; SMN2CTSDHPGDPIK3CG | |
| SCHEMBL22926821 | 0.71 | PLAU (0.45) | MAPTPDE7ABACE1CYP3A4TSHR | |
| SCHEMBL10647219 | 0.71 | APP (0.56) | MAPTAPPMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |