Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042912 | 0.80 | TSHR (0.73) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5921857 | 0.76 | TSHR (0.74) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL31053020 | 0.75 | TSHR (0.59) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL10917076 | 0.75 | ALDH1A1 (0.59) | TSHRALDH1A1GPR35VCAM1HSD17B10 | |
| SCHEMBL10980175 | 0.73 | TSHR (0.63) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28177204 | 0.73 | GPR35 (0.50) | TSHRALDH1A1GPR35VCAM1HPGD | |
| SCHEMBL8562208 | 0.73 | TSHR (0.43) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL38663877 | 0.71 | TSHR (0.65) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| Tecnazene SCHEMBL64355 | 0.71 | TSHR (1.00) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| Tecnazene SCHEMBL3014845 | 0.71 | TSHR (1.00) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596406-B1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |