SCHEMBL8567112

SCHEMBL8567112

Fc1ccc(CCCBr)cc1Oc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.40
LPAR1 Q92633 3/20 0.39
LPAR5 Q9H1C0 3/20 0.39
FDFT1 P37268 2/20 0.39
HRH1 P35367 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9681679 0.91 TDP1 (0.42) TTRHRH1POLB
SCHEMBL9804282 0.85 TTR (0.46) TTRLPAR1LPAR5POLB
SCHEMBL10335055 0.85 TTR (0.40) TTRLPAR1LPAR5FDFT1HRH1
SCHEMBL3710992 0.84 TTR (0.44) TTRLPAR1LPAR5HRH1
SCHEMBL10446712 0.84 PPARG (0.45) LPAR1LPAR5
SCHEMBL8638059 0.82 TTR (0.44) TTRLPAR1LPAR5FDFT1
SCHEMBL14406381 0.81 TTR (0.45) TTRLPAR1LPAR5HRH1
SCHEMBL11166948 0.81 LPAR1 (0.42) TTRLPAR1LPAR5HRH1
SCHEMBL4342229 0.81 TTR (0.42) TTRHRH1POLB
SCHEMBL9682176 0.81 TTR (0.49) TTRHRH1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10226661-A None JP disclosed
JP-10226661-A None JP disclosed
JP-10175905-A None JP disclosed
JP-H10226661-A PRODUCTION OF 1-FLUORO-2-PHENOXY-4-(3-BROMOPROPYL)BENZENE SUMITOMO CHEM CO LTD 1998-08-25 JP disclosed
JP-H10226661-A PRODUCTION OF 1-FLUORO-2-PHENOXY-4-(3-BROMOPROPYL)BENZENE SUMITOMO CHEM CO LTD 1998-08-25 JP disclosed
JP-H10175905-A 1-ALKOXY-3-(4-FLUORO-3-PHENOXYPHENYL)PROPANE, ITS PRODUCTION AND USE THEREOF SUMITOMO CHEM CO LTD 1998-06-30 JP disclosed
EP-0240121-B1 DIPHENYL ETHER DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-17 EP disclosed
EP-0390228-A2 Chemical intermediates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-10-03 EP disclosed
US-4883789-A Substituted phenyltrialkylsilane insecticides FMC CORPORATION (US) 1989-11-28 US disclosed
US-4791139-A Diphenyl ether derivatives and their use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-12-13 US disclosed
US-4709068-A NONTOXIC TO FISH FMC CORPORATION (US) 1987-11-24 US disclosed
US-4701563-A INSECTICIDE, MITICIDE SCHERING AKTIENGESELLSCHAFT (DE) 1987-10-20 US disclosed
EP-0240121-A2 Diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-07 EP disclosed
CN-86102369-A The preparation of difluoro cyclopropane derivative and application thereof 1986-11-19 CN disclosed
EP-0198791-A1 Difluorocyclopropane derivatives, process for their preparation and pesticides containing these compounds SCHERING AKTIENGESELLSCHAFT (DE) 1986-10-22 EP disclosed