Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567267 | 1.00 | ITGB3 (0.50) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 | |
| SCHEMBL8563606 | 0.88 | KMT2A (0.49) | KMT2AALDH1A1MEN1POLBMAPT | |
| SCHEMBL8563604 | 0.88 | KMT2A (0.49) | KMT2AALDH1A1MEN1POLBMAPT | |
| SCHEMBL6438360 | 0.84 | ITGB3 (0.64) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 | |
| SCHEMBL10660397 | 0.84 | ITGB3 (0.64) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 | |
| SCHEMBL4361126 | 0.84 | ITGB3 (0.64) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 | |
| SCHEMBL18659591 | 0.82 | ALOX15 (0.43) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 | |
| SCHEMBL27922392 | 0.81 | ACACB (0.61) | MTNR1AMTNR1B | |
| SCHEMBL27922388 | 0.81 | ACACB (0.61) | MTNR1AMTNR1B | |
| SCHEMBL27850539 | 0.81 | ITGB3 (0.60) | ITGB3ITGA2BKMT2AFPR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948523-A1 | PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1999-10-13 | — | — | EP | disclosed |
| EP-0552060-B1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO (JP) | 1998-11-18 | — | — | EP | disclosed |
| WO-1998029435-A1 | PEPTIDOMIMETIC INHIBITORS OF THE HUMAN CYTOMEGALOVIRUS PROTEASE | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 1998-07-09 | — | — | WO | disclosed |
| EP-0700911-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1996-03-13 | — | — | EP | disclosed |
| US-5472965-A | Useful for treatment of retrovirus infections; less toxic | SHIONOGI & CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5326780-A | Acquired immunodeficiency syndrome | SHIONOGI & CO., LTD. (JP) | 1994-07-05 | — | — | US | disclosed |
| EP-0552060-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |