Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563604 | 1.00 | KMT2A (0.49) | KMT2AALDH1A1POLBTACR1MTNR1A | |
| SCHEMBL8567267 | 0.88 | ITGB3 (0.50) | KMT2AALDH1A1POLBMTNR1AMTNR1B | |
| SCHEMBL8567271 | 0.88 | ITGB3 (0.50) | KMT2AALDH1A1POLBMTNR1AMTNR1B | |
| SCHEMBL6139248 | 0.85 | POLB (0.61) | KMT2AALDH1A1POLBTACR1MTNR1A | |
| SCHEMBL30082808 | 0.85 | POLB (0.61) | KMT2AALDH1A1POLBTACR1MTNR1A | |
| SCHEMBL5706152 | 0.84 | ACACB (0.58) | KMT2AALDH1A1TACR1ATMHSD17B10 | |
| SCHEMBL6662892 | 0.84 | ACACB (0.58) | KMT2AALDH1A1TACR1ATMHSD17B10 | |
| SCHEMBL10477398 | 0.82 | CYP3A4 (0.42) | KMT2APOLBTACR1MTNR1AMTNR1B | |
| SCHEMBL2674354 | 0.82 | ALDH1A1 (0.49) | KMT2AALDH1A1TACR1MEN1 | |
| SCHEMBL2674352 | 0.82 | ALDH1A1 (0.49) | KMT2AALDH1A1TACR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552060-B1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0700911-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1996-03-13 | — | — | EP | disclosed |
| US-5472965-A | Useful for treatment of retrovirus infections; less toxic | SHIONOGI & CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5326780-A | Acquired immunodeficiency syndrome | SHIONOGI & CO., LTD. (JP) | 1994-07-05 | — | — | US | disclosed |
| EP-0552060-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-4058642-A | HYPERTENSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1977-11-15 | — | — | US | disclosed |