Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31015426 | 0.94 | BCHE (0.50) | CCR5HSD11B1ACHEBCHE | |
| SCHEMBL31015593 | 0.92 | BCHE (0.53) | CCR5HSD11B1ACHEBCHE | |
| SCHEMBL31015510 | 0.91 | CCR5 (0.52) | CCR5HSD11B1ACHEBCHE | |
| SCHEMBL34474746 | 0.90 | CCR5 (0.53) | CCR5HSD11B1OPRM1CHRM2CHRM3 | |
| SCHEMBL7499304 | 0.90 | CCR5 (0.53) | CCR5HSD11B1OPRM1CHRM2CHRM3 | |
| SCHEMBL8189152 | 0.88 | CCR5 (0.58) | CCR5OPRM1CHRM2CHRM3ACHE | |
| SCHEMBL12347237 | 0.87 | OPRM1 (0.51) | CCR5HSD11B1OPRM1CHRM2CHRM3 | |
| SCHEMBL8578092 | 0.86 | HSD11B1 (0.48) | CCR5HSD11B1OPRM1CHRM2CHRM3 | |
| SCHEMBL8574081 | 0.86 | HSD11B1 (0.51) | CCR5HSD11B1OPRM1CHRM2CHRM3 | |
| SCHEMBL34473196 | 0.86 | HSD11B1 (0.48) | CCR5HSD11B1OPRM1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871628-A1 | QUINOLIZINONE TYPE COMPOUNDS | Abbott Laboratories (US) | 1998-10-21 | — | — | EP | disclosed |
| US-5726182-A | TREATMENT OF BACTERIAL INFECTIONS | ABBOTT LABORATORIES (US) | 1998-03-10 | — | — | US | disclosed |
| US-5599816-A | BACTERICIDE | ABBOTT LABORATORIES (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |