Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570195 | 0.89 | NOTUM (0.56) | NOTUMALDH1A1POLBSMN1; SMN2PKLR | |
| SCHEMBL6269801 | 0.86 | NOTUM (0.56) | NOTUMALDH1A1POLBSMN1; SMN2PKLR | |
| SCHEMBL6805438 | 0.82 | ALDH1A1 (0.53) | NOTUMALDH1A1POLBSMN1; SMN2PKLR | |
| SCHEMBL7825721 | 0.82 | BRD4 (0.40) | NOTUMALDH1A1POLBSMN1; SMN2MEN1 | |
| SCHEMBL7416927 | 0.79 | NOTUM (0.62) | NOTUMSMN1; SMN2PKLRMEN1KMT2A | |
| SCHEMBL32673424 | 0.79 | NOTUM (0.62) | NOTUMALDH1A1PKLRMEN1KMT2A | |
| SCHEMBL2205547 | 0.77 | LMNA (0.68) | NOTUMALDH1A1POLBSMN1; SMN2PKLR | |
| SCHEMBL14756003 | 0.76 | BRD4 (0.53) | NOTUMALDH1A1MEN1KMT2A | |
| SCHEMBL10167044 | 0.74 | NOTUM (1.00) | NOTUMALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2586534 | 0.74 | NOTUM (1.00) | NOTUMALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |