Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL9451549 | 1.00 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| Acetone SCHEMBL8766802 | 1.00 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL2548348 | 0.95 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL2548351 | 0.95 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL4621606 | 0.95 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL4335282 | 0.90 | CYP2D6 (0.47) | STAT3DHODHALDH1A1CA1CA2 | |
| SCHEMBL19067491 | 0.90 | STAT3 (0.39) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL4343843 | 0.90 | CYP2D6 (0.47) | STAT3DHODHALDH1A1CA1CA2 | |
| SCHEMBL140992 | 0.87 | STAT3 (0.46) | STAT3DHODHALDH1A1CTDSP1SIRT5 | |
| SCHEMBL5471045 | 0.83 | STAT3 (0.43) | STAT3DHODHALDH1A1CTDSP1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798354-A | COSMETIC, THERAPY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-08-25 | — | — | US | disclosed |
| EP-0679631-B1 | Biaromatic acetylated, an adamantyl group containing compounds, pharmaceutical and cosmetic compositions containing them and their use | CIRD GALDERMA (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5574036-A | Adamantyl-substituted polycyclic acetylene compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1996-11-12 | — | — | US | disclosed |
| EP-0679631-A1 | Biaromatic acetylated, an adamantyl group containing compounds, pharmaceutical and cosmetic compositions containing them and their use | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-11-02 | — | — | EP | disclosed |
| US-5273993-A | Antiarthritic agents; osteoporosis | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-12-28 | — | — | US | disclosed |
| US-5194446-A | Antiarthritic agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-16 | — | — | US | disclosed |
| US-5192785-A | Sulfamates as antiglaucoma agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1993-03-09 | — | — | US | disclosed |
| US-5025031-A | Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants | A. H. ROBINS CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0403185-A2 | Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4692450-A | Phenyl-pyrimidinium, thiazolium or imidazolium salts and use in inhibiting intestinal resorption of cholesterol and bile salts | HOFFMANN-LA ROCHE INC. (US) | 1987-09-08 | — | — | US | disclosed |
| US-4675328-A | CHOLESTROL AND BILE SALTS | HOFFMANN-LAROCHE INC. (US) | 1987-06-23 | — | — | US | disclosed |
| US-4506079-A | AROMATIZATION HYPOTENSIVE AGENTS, VASODILATION | SHIONOGI & CO., LTD. (JP) | 1985-03-19 | — | — | US | disclosed |