Acetone

Acetone

SCHEMBL8766802

CC(C)=O.Cc1ccc(S(=O)(=O)OC[C@H](O)CO)cc1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 2/20 0.43
DHODH Q02127 1/20 0.40
ALDH1A1 P00352 5/20 0.39
CTDSP1 Q9GZU7 1/20 0.38
SIRT5 Q9NXA8 1/20 0.38
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA4 P22748 2/20 0.38
CA7 P43166 2/20 0.38
CA9 Q16790 2/20 0.38
KDM4E B2RXH2 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C19 P33261 1/20 0.36
PKM P14618 1/20 0.36
KMT2A Q03164 1/20 0.36
GAA P10253 1/20 0.36
CYP2D6 P10635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetone SCHEMBL9451549 1.00 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5
Acetone SCHEMBL8568091 1.00 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL2548348 0.95 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL2548351 0.95 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL4621606 0.95 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL4335282 0.90 CYP2D6 (0.47) STAT3DHODHALDH1A1CA1CA2
SCHEMBL19067491 0.90 STAT3 (0.39) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL4343843 0.90 CYP2D6 (0.47) STAT3DHODHALDH1A1CA1CA2
SCHEMBL140992 0.87 STAT3 (0.46) STAT3DHODHALDH1A1CTDSP1SIRT5
SCHEMBL5471045 0.83 STAT3 (0.43) STAT3DHODHALDH1A1CTDSP1SIRT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0584191-B1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS CIRD GALDERMA (FR) 1997-08-13 EP disclosed
US-5547983-A Aromatic and polycyclic compounds and their use in human or veterinary medicine and in cosmetics CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1996-08-20 US disclosed
EP-0584191-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS. CIRD GALDERMA (FR) 1994-03-02 EP disclosed
WO-1992019583-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) 1992-11-12 WO disclosed
US-4692450-A Phenyl-pyrimidinium, thiazolium or imidazolium salts and use in inhibiting intestinal resorption of cholesterol and bile salts HOFFMANN-LA ROCHE INC. (US) 1987-09-08 US disclosed
US-4675328-A CHOLESTROL AND BILE SALTS HOFFMANN-LAROCHE INC. (US) 1987-06-23 US disclosed