Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007236 | 0.85 | TP53 (0.63) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL3067363 | 0.82 | L3MBTL1 (0.64) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL1757508 | 0.81 | KDM4E (0.59) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL8568160 | 0.81 | TP53 (0.56) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL11557387 | 0.81 | KMT2A (0.75) | KDM4EKMT2AALDH1A1L3MBTL1POLB | |
| SCHEMBL14994342 | 0.79 | MEN1 (0.70) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL1779695 | 0.77 | RAB9A (0.68) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL24480011 | 0.76 | ALDH1A1 (0.74) | TP53TSHRKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5786592 | 0.75 | TP53 (0.60) | TP53TSHRKDM4EMEN1KMT2A | |
| SCHEMBL29930196 | 0.75 | GRIN2B (0.58) | TP53TSHRKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |