Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392432 | 0.87 | MEN1 (0.44) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL10992183 | 0.85 | POLQ (0.48) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL6873689 | 0.84 | POLQ (0.53) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL29907879 | 0.84 | POLQ (0.53) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL19751892 | 0.83 | POLQ (0.52) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL28057817 | 0.83 | GAA (0.52) | POLQHDAC1HDAC8EPHX2ALDH1A1 | |
| SCHEMBL9890749 | 0.82 | P2RX7 (0.46) | POLQHDAC1HDAC8EPHX2P2RX7 | |
| SCHEMBL265536 | 0.80 | POLQ (0.59) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL31173765 | 0.80 | POLQ (0.59) | POLQHDAC1HDAC8SIGMAR1ANO1 | |
| SCHEMBL6864363 | 0.80 | POLQ (0.58) | POLQHDAC1HDAC8SIGMAR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |