Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568425 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4ECYP2D6POLB | |
| SCHEMBL8568418 | 1.00 | MTNR1A (0.51) | MTNR1AMTNR1BKDM4ECYP2D6POLB | |
| SCHEMBL4800164 | 0.92 | HPGD (0.56) | MTNR1AMTNR1BKDM4ECYP2D6POLB | |
| SCHEMBL17432673 | 0.92 | HPGD (0.56) | MTNR1AMTNR1BKDM4ECYP2D6POLB | |
| SCHEMBL6359841 | 0.83 | PKM (0.53) | KDM4ECYP2D6POLBCYP2C19HPGD | |
| SCHEMBL7499391 | 0.82 | MTNR1A (0.46) | MTNR1AMTNR1BKDM4EPOLBHPGD | |
| SCHEMBL8560985 | 0.79 | MTNR1A (0.52) | MTNR1AMTNR1BHPGDALDH1A1EPHX2 | |
| SCHEMBL8560988 | 0.79 | MTNR1A (0.52) | MTNR1AMTNR1BHPGDALDH1A1EPHX2 | |
| SCHEMBL8560984 | 0.79 | MTNR1A (0.52) | MTNR1AMTNR1BHPGDALDH1A1EPHX2 | |
| SCHEMBL7044762 | 0.79 | MAPT (0.54) | KDM4ECYP2D6HPGDPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |