Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | BRD1 | O95696 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8565340 | 0.99 | PKM (0.43) | PKMHTR6TRIM24BRD1BRPF1 | |
| SCHEMBL8913770 | 0.90 | ADRA1D (0.41) | KCNH2 | |
| SCHEMBL267585 | 0.79 | ADRA1D (0.56) | KCNH2 | |
| Hydrochloric Acid SCHEMBL8912554 | 0.79 | EPHX2 (0.52) | PKMTRIM24BRD1BRPF1HRH3 | |
| Hydrochloric Acid SCHEMBL261711 | 0.78 | ADRA1D (0.55) | KCNH2 | |
| SCHEMBL8914795 | 0.78 | HDAC3 (0.41) | KCNH2NR3C2 | |
| Hydrochloric Acid SCHEMBL8912935 | 0.77 | HDAC3 (0.41) | KCNH2NR3C2 | |
| SCHEMBL7849142 | 0.77 | ADRA1D (0.56) | KCNH2 | |
| Hydrochloric Acid SCHEMBL8912790 | 0.76 | HTR6 (0.37) | HTR6MLNRNR3C2HTR2A | |
| SCHEMBL8566857 | 0.76 | ADRA1D (0.47) | KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |