Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568695 | 1.00 | PTGS2 (0.38) | PTGS2MMP14PTGS1MMP13GAA | |
| SCHEMBL7495878 | 0.80 | PTGS2 (0.36) | PTGS2PTGS1BCHEACHE | |
| SCHEMBL7495881 | 0.80 | PTGS2 (0.36) | PTGS2PTGS1BCHEACHE | |
| SCHEMBL7495875 | 0.80 | PTGS2 (0.36) | PTGS2PTGS1BCHEACHE | |
| SCHEMBL8925412 | 0.80 | PTGS2 (0.36) | PTGS2PTGS1BCHEACHE | |
| SCHEMBL7490779 | 0.70 | ENPP2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL7490776 | 0.70 | ENPP2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL7490774 | 0.70 | ENPP2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL8189822 | 0.68 | MMP14 (0.36) | PTGS2MMP14PTGS1GAA | |
| SCHEMBL8189819 | 0.68 | MMP14 (0.36) | PTGS2MMP14PTGS1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863891-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997014691-A1 | (METHYLSULFONYL)PHENYL-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-04-24 | — | — | WO | disclosed |