Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9664850 | 0.87 | KCNA5 (0.52) | HPGDALDH1A1KCNA5HDAC1TSHR | |
| SCHEMBL2061998 | 0.83 | KCNA5 (0.54) | HPGDALDH1A1KDM4ERCE1KCNA5 | |
| SCHEMBL10416108 | 0.81 | HPGD (0.57) | HPGDALDH1A1KDM4ERCE1HDAC1 | |
| SCHEMBL28584573 | 0.81 | ALDH1A1 (0.47) | HPGDALDH1A1KDM4ERCE1KCNA5 | |
| SCHEMBL13310201 | 0.81 | HPGD (0.47) | HPGDALDH1A1KDM4ERCE1KCNA5 | |
| SCHEMBL15939820 | 0.81 | NPC1 (0.60) | HPGDALDH1A1KDM4ERCE1CYP3A4 | |
| SCHEMBL28333273 | 0.80 | ALDH1A1 (0.62) | HPGDALDH1A1KDM4ETSHRHTT | |
| Hydrochloric Acid SCHEMBL27934631 | 0.80 | HPGD (0.55) | HPGDALDH1A1KDM4ERCE1HDAC1 | |
| SCHEMBL7801637 | 0.80 | ALDH1A1 (0.55) | HPGDALDH1A1KDM4ERCE1HDAC1 | |
| SCHEMBL28029765 | 0.79 | HPGD (0.54) | HPGDALDH1A1KDM4ERCE1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |