Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 6/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089043 | 0.84 | HPGD (0.51) | ALDH1A1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3416627 | 0.83 | RIPK1 (0.52) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL6498349 | 0.82 | TSHR (0.60) | ALDH1A1KDM4ERAB9ANPC1TSHR | |
| SCHEMBL11472039 | 0.82 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL17773307 | 0.81 | RAB9A (0.47) | SMN1; SMN2RAB9ANPC1LMNATSHR | |
| SCHEMBL15738726 | 0.81 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL28593323 | 0.80 | NPC1 (0.58) | ALDH1A1SMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL8568942 | 0.80 | HPGD (0.57) | ALDH1A1HSD17B10KDM4ERAB9ANPC1 | |
| SCHEMBL3806762 | 0.79 | EPHX2 (0.56) | ALDH1A1POLBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7799195 | 0.79 | SMN1; SMN2 (0.51) | ALDH1A1POLBSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163220-A1 | TRICYCLIC INDOLE-2-CARBOXYLIC ACID COMPOUND USED AS NMDA RECEPTOR ANTAGONIST | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056711-A1 | TRICYCLIC INDOLE-2-CARBOXYLIC ACID COMPOUND USED AS NMDA RECEPTOR ANTAGONIST | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2000-09-28 | — | — | WO | disclosed |