Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 8/20 | 0.71 |
| ▸ | FPR2 | P25090 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2683547 | 1.00 | FPR3 (0.71) | FPR3FPR2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL855441 | 0.88 | FPR3 (0.67) | FPR3FPR2ALDH1A1CNR1P2RX7 | |
| SCHEMBL2682344 | 0.88 | FPR3 (0.67) | FPR3FPR2ALDH1A1CNR1P2RX7 | |
| SCHEMBL856708 | 0.84 | FPR3 (0.76) | FPR3FPR2ALDH1A1SMN1; SMN2TAAR1 | |
| SCHEMBL2682166 | 0.84 | FPR3 (0.76) | FPR3FPR2ALDH1A1SMN1; SMN2TAAR1 | |
| SCHEMBL2682717 | 0.83 | FPR3 (1.00) | FPR3FPR2 | |
| SCHEMBL20013750 | 0.72 | ALDH1A1 (1.00) | FPR3FPR2ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL3529974 | 0.72 | HPGD (0.67) | ALDH1A1TDP1HPGDCNR1METAP2 | |
| SCHEMBL2683287 | 0.72 | FPR3 (0.74) | FPR3FPR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2684819 | 0.71 | FPR3 (1.00) | FPR3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |