Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 2/20 | 0.66 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.60 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.60 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.60 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | METAP2 | P50579 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28753564 | 0.85 | HPGD (0.50) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL4038474 | 0.85 | HPGD (0.69) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL19376791 | 0.83 | HPGD (0.49) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7405242 | 0.83 | HPGD (0.49) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL27611366 | 0.83 | HPGD (0.49) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL697972 | 0.82 | ALDH1A1 (0.63) | CNR1ALDH1A1TDP1LMNA | |
| SCHEMBL5654926 | 0.82 | HPGD (0.48) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL13034051 | 0.82 | CNR1 (0.57) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL17330349 | 0.81 | HPGD (0.47) | HPGDCNR1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL16795265 | 0.81 | HPGD (0.52) | HPGDCNR1PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |
| US-7825149-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | HPGD 2124/4885CNR1 1586/4885PLAAT3 4504/4885 |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | HPGD 2124/4885CNR1 1586/4885PLAAT3 4504/4885 |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | HPGD 2124/4885CNR1 1586/4885PLAAT3 4504/4885 |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | ABL1, TYR, CYP3A4 | HPGD 2124/4885CNR1 1586/4885PLAAT3 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.