SCHEMBL8569288

SCHEMBL8569288

C[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](CN1C(=O)c2ccccc2C1=O)C(=O)OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.45
RAB9A P51151 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 2/20 0.38
USP2 O75604 1/20 0.38
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CTRB1 P17538 1/20 0.37
ELANE P08246 2/20 0.37
MMP1 P03956 1/20 0.37
MMP2 P08253 1/20 0.37
MMP3 P08254 1/20 0.37
MMP9 P14780 1/20 0.37
MMP8 P22894 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8570991 0.81 ALDH1A1 (0.41) MAPK1MEN1KMT2AHSD17B10ELANE
SCHEMBL7375195 0.79 MMP1 (0.46) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL7375197 0.79 MMP1 (0.46) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL7371909 0.79 MMP1 (0.46) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL23501319 0.77 MAPK1 (0.43) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL7373620 0.77 MAPK1 (0.49) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL7373619 0.77 MAPK1 (0.49) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL7373763 0.77 MAPK1 (0.49) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL9219312 0.76 AVPR1A (0.44) MAPK1RAB9ACYP3A4CYP2D6CYP2C9
SCHEMBL9219306 0.76 AVPR1A (0.44) MAPK1RAB9ACYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5831091-A Process for preparing acetoxyazetidinone derivative and intermediate thereof TANABE SEIYAKU CO., LTD. (JP) 1998-11-03 US disclosed
EP-0774463-A1 Process for preparing acetoxyazetidinone derivative and intermediates thereof TANABE SEIYAKU CO., LTD. (JP) 1997-05-21 EP disclosed