Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6345643 | 0.86 | MAPT (0.64) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL13440495 | 0.84 | TP53 (0.60) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL11571840 | 0.84 | MAPT (0.86) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL27611956 | 0.84 | MAPT (0.72) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL8569129 | 0.83 | ALDH1A1 (0.62) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL31344385 | 0.83 | MAPT (0.60) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL7072156 | 0.82 | MAPT (0.70) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL11827090 | 0.82 | MAPT (0.72) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL31000396 | 0.82 | MAPT (0.72) | MAPTALDH1A1LMNATP53GAA | |
| SCHEMBL4083067 | 0.82 | NR4A1 (0.53) | MAPTALDH1A1LMNATP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-4099002-A | QUINAZOLINONE DERIVATIVES AND A PROCESS FOR PRODUCTION THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-07-04 | — | — | US | disclosed |
| US-3980645-A | Fused quinazolinones and a process for production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-09-14 | — | — | US | disclosed |