SCHEMBL8569396

SCHEMBL8569396

O=C(CCCCCl)c1c(Cl)c(Cl)cc2c1OCCO2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 3/20 0.34
WNT3A P56704 3/20 0.34
LARS1 Q9P2J5 2/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
HPGD P15428 2/20 0.33
ALDH1A1 P00352 3/20 0.33
TP53 P04637 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
KLF5 Q13887 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7351377 0.75 KDM4E (0.38) LARS1ALDH1A1LMNAMAPTTDP1
SCHEMBL8569414 0.69 CTNNB1 (0.60) CTNNB1WNT3AMAPTHDAC3HDAC4
SCHEMBL4855167 0.69 NPC1 (0.43) CTNNB1WNT3ASMN1; SMN2NPC1RAB9A
SCHEMBL4855229 0.69 HPGD (0.66) CTNNB1WNT3ASMN1; SMN2NPC1RAB9A
SCHEMBL6706298 0.67 AHR (0.48) LARS1NPC1RAB9AHDAC3HDAC4
SCHEMBL13481422 0.66 LARS1 (0.38) LARS1SMN1; SMN2NPC1HPGDLMNA
SCHEMBL5312945 0.64 PTGS2 (0.48) CTNNB1WNT3ANPC1
SCHEMBL7483165 0.64 HPGD (0.68) CTNNB1WNT3ASMN1; SMN2NPC1RAB9A
SCHEMBL4857484 0.63 CTNNB1 (0.56) CTNNB1WNT3ASMN1; SMN2NPC1RAB9A
SCHEMBL27432422 0.62 ALDH1A1 (0.49) SMN1; SMN2NPC1RAB9AHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739336-A SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS SYNTEX (U.S.A.) INC. (US) 1998-04-14 US disclosed
WO-1997000872-A1 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 1997-01-09 WO disclosed