Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 6/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679986 | 0.84 | KMT2A (0.55) | CDK5CDK5R1HTTNPC1RAB9A | |
| SCHEMBL5365864 | 0.83 | CES2 (0.51) | PARP1CES2CES1STSHTT | |
| SCHEMBL28747256 | 0.83 | CES2 (0.51) | CDK5CDK5R1PARP1CES2CES1 | |
| SCHEMBL8694860 | 0.82 | KMT2A (0.56) | CDK5CDK5R1PARP1CES2CES1 | |
| SCHEMBL7370589 | 0.82 | ALDH1A1 (0.55) | PARP1CES2CES1STSHTT | |
| SCHEMBL3244377 | 0.81 | CES2 (0.49) | CDK5CDK5R1PARP1CES2CES1 | |
| SCHEMBL7369720 | 0.81 | ELANE (0.49) | CDK5CDK5R1PARP1CES2CES1 | |
| SCHEMBL29476675 | 0.81 | MKNK1 (0.56) | CDK5CDK5R1PARP1CES2CES1 | |
| SCHEMBL7921178 | 0.81 | KMT2A (0.44) | KDM4EMEN1KMT2ANAPRTALDH1A1 | |
| SCHEMBL4267213 | 0.80 | GAA (0.59) | PARP1CES2CES1STSHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |