Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9676236 | 0.78 | NPC1 (0.51) | METBRPF1KDM4EALDH1A1LMNA | |
| SCHEMBL8996768 | 0.77 | MET (0.47) | METBRPF1KDM4EALDH1A1LMNA | |
| SCHEMBL13177201 | 0.77 | KDM4E (0.58) | KDM4EALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL9676242 | 0.76 | KCNH2 (0.51) | METBRPF1KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2921145 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL10364802 | 0.75 | CYP2D6 (0.47) | SMN1; SMN2KCNH2 | |
| SCHEMBL10341272 | 0.74 | KCNH2 (0.44) | METKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL26352480 | 0.74 | RAB9A (0.53) | METBRPF1KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9678085 | 0.73 | KCNH2 (0.43) | METKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL9716427 | 0.73 | MET (0.39) | METBRPF1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | claimed |
| CN-1038451-A | Antiarrhythmics | PFIZER LTD (GB) | 1990-01-03 | — | — | CN | claimed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | claimed |
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5158964-A | Benzoxazole sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5130334-A | INDANE SULFONAMIDE ANTI-ARRHYTHMIC AGENTS | PFIZER INC. (US) | 1992-07-14 | — | — | US | disclosed |
| CN-1015804-B | METHOD FOR PREPARATION OF SULPHONIC ACID AMIDE COMPOUND FOR ANTIARRHYTHMIC AGENT | PFIZER LTD (GB) | 1992-03-11 | — | — | CN | disclosed |
| US-5055473-A | QUINOLINYL SULFONAMIDE ANTI-ARRHYTHMIC AGENTS AND USE THEREAS | PFIZER INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4956382-A | TERTIARY AMINE HETEROCYCLIC SULFONAMIDES | PFIZER INC. (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | disclosed |
| CN-1038451-A | Antiarrhythmics | PFIZER LTD (GB) | 1990-01-03 | — | — | CN | disclosed |
| US-4829071-A | Quinolyl substituted indane sulfonamides and their use as anti-arrhythmic agents | PFIZER INC. (US) | 1989-05-09 | — | — | US | disclosed |
| EP-0286277-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-10-12 | — | — | EP | disclosed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | disclosed |