SCHEMBL8569813

SCHEMBL8569813

COc1cc(F)c(-c2nn(C)c(C(F)(F)F)c2Cl)cc1[N+](=O)[O-]

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.35
TDP1 Q9NUW8 2/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
HIF1A Q16665 1/20 0.35
TXNRD1 Q16881 1/20 0.35
TXNRD3 Q86VQ6 1/20 0.35
TXNRD2 Q9NNW7 1/20 0.35
SIRT6 Q8N6T7 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
LMNA P02545 4/20 0.32
MAPT P10636 2/20 0.32
HTT P42858 2/20 0.32
TMEM97 Q5BJF2 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
S1PR4 O95977 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8566841 0.96 ALDH1A1 (0.35) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL8569450 0.87 SMN1; SMN2 (0.33) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL6843950 0.87 TDP1 (0.39) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL6849426 0.86 PPARD (0.32) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL8566176 0.85 ALDH1A1 (0.39) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL8566681 0.85 PKM (0.39) ALDH1A1MAPTKMT2AMEN1
SCHEMBL7747330 0.84 RAB9A (0.33) ALDH1A1CYP3A4HPGDALOX15TSHR
SCHEMBL8571516 0.84 ALDH1A1 (0.37) ALDH1A1TDP1CYP3A4HPGDALOX15
SCHEMBL8570112 0.83 MAPT (0.34) ALDH1A1TDP1SIRT6CYP1A2CYP2C19
SCHEMBL9538983 0.83 SMN1; SMN2 (0.33) ALDH1A1TDP1CYP3A4HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0553307-B1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO CO (US) 1998-12-09 EP disclosed
EP-0791571-A1 Benzoyl derivatives MONSANTO COMPANY (US) 1997-08-27 EP disclosed
US-5536700-A Herbicidal compositions comprising aryl-5-haloalkylpyrazoles and glyphosate, it's salts, diquat or paraquat MONSANTO COMPANY (US) 1996-07-16 US disclosed
US-5530126-A ALKYLATION IN INERT SOLVENT MONSANTO COMPANY (US) 1996-06-25 US disclosed
US-5496956-A BY ESTERIFICATION OF CARBOXY SUBSTITUTION WITH ALCOHOLS IN THE PRESENCE OF MINERAL ACID MONSANTO COMPANY (US) 1996-03-05 US disclosed
US-5489571-A CROP-SAFE COMPOUNDS EFFECTIVE AT LOW CONCENTRATIONS MONSANTO COMPANY (US) 1996-02-06 US disclosed
US-5281571-A Herbicidal benzoxazinone- and benzothiazinone-substituted pyrazoles MONSANTO COMPANY (US) 1994-01-25 US disclosed
EP-0553307-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1993-08-04 EP disclosed
WO-1992006962-A1 HERBICIDAL SUBSTITUTED ARYL-HALOALKYLPYRAZOLES MONSANTO COMPANY (US) 1992-04-30 WO disclosed