SCHEMBL857

SCHEMBL857

O=[C]OC(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.39
TDO2 P48775 4/20 0.39
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
CYP2D6 P10635 3/20 0.37
SRC P12931 1/20 0.37
CYP1A2 P05177 2/20 0.36
SCN1A P35498 2/20 0.36
SCN2A Q99250 2/20 0.36
SCN3A Q9NY46 2/20 0.36
TSHR P16473 2/20 0.36
LMNA P02545 2/20 0.36
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
IDO2 Q6ZQW0 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
ADRA2A P08913 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5537747 0.88 IDO1 (0.58) IDO1TDO2CYP2D6CYP1A2TSHR
SCHEMBL5536659 0.88 IDO1 (0.45) IDO1TDO2LMNASMN1; SMN2NPSR1
SCHEMBL11084293 0.84 ACP3 (0.53) NPSR1
SCHEMBL5541590 0.83 IDO1 (0.60) IDO1TDO2LMNA
SCHEMBL5545080 0.83 ACP3 (0.46) IDO1TDO2LMNAIDO2DRD3
SCHEMBL5827346 0.82 ALDH1A1 (0.48) LMNASMN1; SMN2NPSR1HTTMAPK1
SCHEMBL8173801 0.80 F7 (0.47) PKMF2
SCHEMBL5450128 0.78 KMT2A (0.33) CYP2D6CYP1A2SCN1ASCN2ASCN3A
SCHEMBL6421761 0.78 LMNA (0.39) IDO1TDO2CYP2D6SRCTSHR
SCHEMBL11807847 0.76 IDO1 (0.46) IDO1TDO2CYP2D6IDO2SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7492 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4326740-A1 PEPTIDE NUCLEIC ACIDS, SYNTHESIS, AND USES THEREOF Ongogenuity, Inc. (US) 2024-02-28 EP claimed
US-20230108350-A1 METHOD FOR PRODUCING PNA OLIGOMER IN SOLUTION PROCESS SEASUNBIO MATERIALS (KP) 2023-04-06 US claimed
EP-4136083-A1 THYCLOTIDES The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2023-02-22 EP claimed
CN-114671798-B Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-08-16 CN claimed
CN-114901673-A Method for preparing solution phase peptide nucleic acid oligomer 海阳生物材料有限公司 2022-08-12 CN claimed
US-20220202800-A1 Method of Treatment of Organic Acidemias and Other Mitochondria Defects or Deficiencies UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2022-06-30 US claimed
CN-114671798-A Green synthesis method of antiviral drug intermediate 上海皓元医药股份有限公司 2022-06-28 CN claimed
CN-114324568-A Sound field auxiliary preparation method of guanine peptide nucleic acid self-assembly nanosphere-based photonic crystal 浙江大学 2022-04-12 CN claimed
US-20210369632-A1 Discoidal Nano Universal Platform for Efficient Delivery of PNAs NATIONAL SCIENCE FOUNDATION 2021-12-02 US claimed
WO-2021211786-A1 THYCLOTIDES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-10-21 WO claimed
US-4024249-A FOR COMBATTING MICROORGANISMS CIBA-GEIGY CORPORATION (US) 1977-05-17 US claimed
US-4017488-A Process for preparing 7β-acylamino-7α-alkoxycephalosporins SANKYO COMPANY LIMITED (JA) 1977-04-12 US claimed
US-4012345-A POLYPEPTIDES WHICH INHIBIT SECRETION OF GROWTH HORMONE SOMATOTROPIN AMERICAN HOME PRODUCTS CORPORATION (US) 1977-03-15 US claimed
US-4012380-A 7-Acylamino-3-acyl-2(or 3)cephems ELI LILLY AND COMPANY (US) 1977-03-15 US claimed
US-4009159-A PENICILLINS FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1977-02-22 US claimed
US-4001239-A CEPHALOSPORIN CLEAVAGE PROCESS ELI LILLY AND COMPANY (US) 1977-01-04 US claimed
US-3997517-A PEPTIDE AMERICAN HOME PRODUCTS CORPORATION (US) 1976-12-14 US claimed
US-3993646-A Process for the ring expansion of penicillins to cephalosporin compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-11-23 US claimed
US-3978063-A 1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JA) 1976-08-31 US claimed
US-3951951-A Azetidinones BEECHAM GROUP LIMITED (EN) 1976-04-20 US claimed