Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.67 |
| ▸ | ATM | Q13315 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.54 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8569150 | 0.90 | CCR3 (0.55) | CCR3ATMALDH1A1GRIN1GRIN2B | |
| Fumaric Acid SCHEMBL8569153 | 0.90 | CCR3 (0.55) | CCR3ATMALDH1A1GRIN1GRIN2B | |
| SCHEMBL2004615 | 0.81 | CCR3 (1.00) | CCR3ATMALDH1A1KDM4EGLA | |
| SCHEMBL5778870 | 0.81 | ATM (0.61) | CCR3ATMALDH1A1KDM4EGLA | |
| SCHEMBL13375731 | 0.80 | DRD2 (0.53) | CCR3ATMDRD2DRD4DRD3 | |
| SCHEMBL7977320 | 0.79 | CCR3 (0.96) | CCR3ATMALDH1A1KDM4EGLA | |
| SCHEMBL8191786 | 0.79 | CCR3 (0.96) | CCR3ATMALDH1A1KDM4EGLA | |
| SCHEMBL3968181 | 0.77 | DRD2 (0.73) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL14375224 | 0.76 | DRD2 (0.55) | ALDH1A1DRD2DRD4DRD3HRH3 | |
| SCHEMBL8574775 | 0.76 | GRIN2B (0.62) | CCR3ATMALDH1A1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760234-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-5750700-A | COMPOUNDS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS SCHIZOPHRENIA, NEUROLEPTIC AGENTS FOR BINDING TO DOPAMINE RECEPTORS | NEUROGEN CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |