Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8569153 | 1.00 | CCR3 (0.55) | CCR3GAAKDM4EATMSMN1; SMN2 | |
| SCHEMBL8570573 | 0.90 | CCR3 (0.67) | CCR3GAAKDM4EATMALDH1A1 | |
| Fumaric Acid SCHEMBL9253095 | 0.75 | CCR3 (0.60) | CCR3GAAKDM4ESMN1; SMN2ALDH1A1 | |
| Fumaric Acid SCHEMBL9253101 | 0.75 | CCR3 (0.60) | CCR3GAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL5778870 | 0.75 | ATM (0.61) | CCR3GAAKDM4EATMALDH1A1 | |
| Maleic Acid SCHEMBL7474095 | 0.74 | DRD4 (0.58) | CCR3GAAKDM4ESMN1; SMN2ALDH1A1 | |
| Pyrrole SCHEMBL8569144 | 0.74 | CCR3 (0.47) | CCR3GAAKDM4ESMN1; SMN2ALDH1A1 | |
| Fumaric Acid SCHEMBL7474099 | 0.74 | DRD4 (0.58) | CCR3GAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2004615 | 0.73 | CCR3 (1.00) | CCR3GAAKDM4EATMALDH1A1 | |
| SCHEMBL13375731 | 0.72 | DRD2 (0.53) | CCR3ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760234-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | claimed |