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Hydrocortisone

Hydrocortisone

SCHEMBL8570579

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 2/20 0.78
▸ HIF1A Q16665 12/20 0.78
▸ SMN1; SMN2 Q16637 7/20 0.78
▸ HSD17B10 Q99714 6/20 0.78
▸ SERPINA6 P08185 6/20 0.78
▸ SHBG P04278 5/20 0.78
▸ CYP3A4 P08684 5/20 0.78
▸ CYP2C19 P33261 3/20 0.78
▸ MAPT P10636 3/20 0.78
▸ NR3C2 P08235 3/20 0.78
▸ NFKB1 P19838 3/20 0.78
▸ PGR P06401 2/20 0.78
▸ KMT2A Q03164 2/20 0.78
▸ LMNA P02545 6/20 0.71
▸ TSHR P16473 3/20 0.71
▸ MAPK1 P28482 2/20 0.71
▸ BLM P54132 2/20 0.71
▸ CYP2C9 P11712 1/20 0.71
▸ SLC22A2 O15244 1/20 0.71
▸ SLC22A1 O15245 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone SCHEMBL5328946 0.94 HIF1A (0.82) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL6715475 0.94 HIF1A (0.78) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Cortisone SCHEMBL5663871 0.94 HSD17B10 (0.69) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL5665147 0.93 HIF1A (0.68) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL5493693 0.92 HIF1A (0.78) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL2330383 0.91 HIF1A (0.82) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Corticosterone SCHEMBL5323007 0.89 SMN1; SMN2 (0.89) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL24900238 0.88 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL1688689 0.88 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL12737556 0.88 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998006439-A1 POLYETHERESTER COPOLYMERS AS DRUG DELIVERY MATRICES OSTEOTECH, INC. (US) 1998-02-19 — — WO disclosed
US-4017597-A STORAGE STABILITY, MEDICAL DIAGNOSIS MONSANTO COMPANY (US) 1977-04-12 — — US disclosed