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Hydrocortisone

Hydrocortisone

SCHEMBL5328946

C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 2/20 0.82
▸ HIF1A Q16665 10/20 0.82
▸ SMN1; SMN2 Q16637 8/20 0.82
▸ HSD17B10 Q99714 6/20 0.82
▸ SERPINA6 P08185 6/20 0.82
▸ SHBG P04278 5/20 0.82
▸ CYP3A4 P08684 5/20 0.82
▸ NR3C2 P08235 4/20 0.82
▸ CYP2C19 P33261 3/20 0.82
▸ MAPT P10636 3/20 0.82
▸ NFKB1 P19838 2/20 0.82
▸ PGR P06401 2/20 0.82
▸ KMT2A Q03164 2/20 0.82
▸ LMNA P02545 6/20 0.80
▸ BLM P54132 2/20 0.80
▸ TSHR P16473 2/20 0.80
▸ MAPK1 P28482 2/20 0.80
▸ CYP2C9 P11712 1/20 0.80
▸ SLC22A2 O15244 1/20 0.80
▸ SLC22A1 O15245 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone SCHEMBL5493693 0.98 HIF1A (0.78) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL8570579 0.94 HIF1A (0.78) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Cortisone SCHEMBL17165698 0.93 HIF1A (0.71) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Cortisone SCHEMBL991784 0.92 HSD17B10 (0.72) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL5665147 0.91 HIF1A (0.68) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL24900238 0.91 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL6932400 0.91 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL19465688 0.91 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL12737556 0.91 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG
Hydrocortisone SCHEMBL5699764 0.91 HIF1A (1.00) HIF1ASMN1; SMN2HSD17B10SERPINA6SHBG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2101731-B1 ENDOXIFEN FOR USE IN THE TREATMENT OF CANCER JINA PHARMACEUTICALS INC (US) 2018-01-31 — — EP claimed
EP-0167825-A2 Lipid nano pellets as drug carriers for oral administration Dr. Rentschler Arzneimittel GmbH & Co. (DE) 1986-01-15 — — EP claimed
EP-3416649-A1 COMPOSITIONS AND METHODS FOR TREATING SUBSTANCE ABUSE DISORDERS Embera Neurotherapeutics, Inc (US) 2018-12-26 — — EP disclosed
WO-2017143034-A1 COMPOSITIONS AND METHODS FOR TREATING SUBSTANCE ABUSE DISORDERS EMBERA NEUROTHERAPEUTICS, INC. (US) 2017-08-24 — — WO disclosed
WO-2007104030-A1 RETINOIDS AND RELATED COMPOUNDS FOR THE TREATMENT OF NEUROINFLAMMATORY CONDITIONS, DISEASES AND DISORDERS KINEMED, INC. (US) 2007-09-13 — — WO disclosed
WO-2000065070-A9 CELL CULTURE PROCESS FOR GLYCOPROTEINS GENENTECH INC (US) 2001-08-02 — — WO disclosed
EP-0167825-B1 LIPID NANO PELLETS AS DRUG CARRIERS FOR ORAL ADMINISTRATION Dr. Rentschler Arzneimittel GmbH & Co. (DE) 1990-08-08 — — EP disclosed
EP-0167825-A2 Lipid nano pellets as drug carriers for oral administration Dr. Rentschler Arzneimittel GmbH & Co. (DE) 1986-01-15 — — EP disclosed
US-4305721-A Agglutination assay BECTON DICKINSON & COMPANY (US) 1981-12-15 — — US disclosed