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Hydrocortisone

Hydrocortisone

SCHEMBL5665147

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O.C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 3/20 0.68
▸ HIF1A Q16665 10/20 0.68
▸ SMN1; SMN2 Q16637 9/20 0.68
▸ CYP3A4 P08684 7/20 0.68
▸ SERPINA6 P08185 7/20 0.68
▸ HSD17B10 Q99714 6/20 0.68
▸ SHBG P04278 6/20 0.68
▸ MAPT P10636 5/20 0.68
▸ NR3C2 P08235 5/20 0.68
▸ CYP2C19 P33261 4/20 0.68
▸ PGR P06401 3/20 0.68
▸ NFKB1 P19838 2/20 0.68
▸ KMT2A Q03164 2/20 0.68
▸ LMNA P02545 8/20 0.66
▸ MAPK1 P28482 4/20 0.66
▸ TSHR P16473 4/20 0.66
▸ CYP2C9 P11712 3/20 0.66
▸ SLC22A2 O15244 2/20 0.66
▸ SLC22A1 O15245 2/20 0.66
▸ SLC22A3 O75751 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrocortisone SCHEMBL6715475 0.93 HIF1A (0.78) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Hydrocortisone SCHEMBL8570579 0.93 HIF1A (0.78) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Corticosterone SCHEMBL5662984 0.92 LMNA (0.78) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Hydrocortisone SCHEMBL5328946 0.91 HIF1A (0.82) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Hydrocortisone SCHEMBL2330383 0.91 HIF1A (0.82) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Hydrocortisone SCHEMBL5493693 0.90 HIF1A (0.78) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Hydroxyprogesterone SCHEMBL5664516 0.90 SMN1; SMN2 (0.71) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Corticosterone SCHEMBL9264007 0.89 LMNA (0.84) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Cortisone SCHEMBL5663871 0.88 HSD17B10 (0.69) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10
Cortodoxone SCHEMBL9710918 0.88 CYP3A4 (0.74) HIF1ASMN1; SMN2CYP3A4SERPINA6HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1404717-A4 KINETIC ASSAY HORTICULTURE & FOOD RES INST (NZ) 2006-03-08 — — EP claimed
EP-1404717-A1 KINETIC ASSAY The Horticulture and Food Research Institute of New Zealand Limited (NZ) 2004-04-07 — — EP claimed
WO-2002092631-A1 KINETIC ASSAY THE HORTICULTURE AND FOOD RESEARCH INSTITUTE OF NEW ZEALAND LIMITED (NZ) 2002-11-21 — — WO claimed