Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746370 | 0.84 | SMN1; SMN2 (0.45) | POLBPKM | |
| SCHEMBL2033633 | 0.83 | SMN1; SMN2 (0.44) | CHRM1CHRM5CHRM3CHRM4CHRM2 | |
| SCHEMBL18359599 | 0.79 | CTSB (0.49) | PKMPKLR | |
| SCHEMBL2798211 | 0.78 | TAAR1 (0.53) | — | |
| SCHEMBL16111739 | 0.78 | PRKCI (0.45) | CHRM1CHRM5CHRM3CHRM4CHRM2 | |
| SCHEMBL24045389 | 0.76 | MAOA (0.48) | POLBKDM4EPKM | |
| SCHEMBL28342389 | 0.76 | CHRM5 (0.53) | CHRM1CHRM5CHRM3CHRM4CHRM2 | |
| SCHEMBL1276487 | 0.76 | RAB9A (0.46) | CHRM1CHRM5CHRM3CHRM4CHRM2 | |
| SCHEMBL4816674 | 0.73 | MAOB (0.44) | — | |
| SCHEMBL14015076 | 0.73 | RAB9A (0.44) | CHRM1CHRM5CHRM3CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |