Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007642 | 0.81 | IMPDH2 (0.55) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL27872217 | 0.81 | IMPDH2 (0.58) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL17461856 | 0.81 | MAPT (0.48) | PLK1EGFRSRCKDM4ENPC1 | |
| SCHEMBL31670359 | 0.81 | NR4A2 (0.55) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL30522265 | 0.81 | NR4A2 (0.55) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL2181558 | 0.81 | NR4A2 (0.55) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL30749415 | 0.80 | PARP1 (0.73) | KDM4EALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL2183473 | 0.80 | PARP1 (0.73) | KDM4EALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL30455376 | 0.80 | PARP1 (0.73) | KDM4EALDH1A1LMNACYP1A2MAPT | |
| SCHEMBL30006934 | 0.78 | IMPDH2 (0.55) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153043-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | HEALTH RESEARCH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| CN-1233176-A | Substituted tricyclics | LILLY CO ELI (US) | 1999-10-27 | — | — | CN | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |