SCHEMBL8575149

SCHEMBL8575149

CC[SiH2]CCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
ALDH1A1 P00352 2/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
CASP1 P29466 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TAAR1 Q96RJ0 3/20 0.43
ATM Q13315 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
CYP2A6 P11509 1/20 0.42
HTR2A P28223 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
AOC3 Q16853 2/20 0.42
CHRM2 P08172 1/20 0.42
HTR1A P08908 1/20 0.42
ADRA2A P08913 1/20 0.42
CHRM1 P11229 1/20 0.42
DRD1 P21728 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8382309 0.85 ALDH1A1 (0.52) ALDH1A1HPGDALOX15ALOX12CASP1
Hydrochloric Acid SCHEMBL1030795 0.82 ALDH1A1 (0.50) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8389964 0.80 SIGMAR1 (0.48) TP53HPGDTAAR1CYP2A6HTR2A
SCHEMBL24849454 0.77 SIGMAR1 (0.50) TP53HPGDHTR2ASMN1; SMN2KCNH2
SCHEMBL8727743 0.77 TRPA1 (0.39) TP53ALDH1A1HPGDALOX15ALOX12
SCHEMBL31216299 0.77 SIGMAR1 (0.50) TP53HPGDHTR2ASMN1; SMN2KCNH2
SCHEMBL8997247 0.76 ALDH1A1 (0.44) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8384814 0.75 ALDH1A1 (0.48) TP53ALDH1A1HPGDALOX15ALOX12
SCHEMBL7170720 0.75 TP53 (0.50) TP53ALDH1A1HPGDALOX15ALOX12
Hydrochloric Acid SCHEMBL4465542 0.73 ALDH1A1 (0.46) TP53ALDH1A1HPGDALOX15ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4424343-A Preparation of 1-N- ω-amino-α-hydroxyalkanoyl!kanamycin polysilylates and products BRISTOL MYERS COMPANY (US) 1984-01-03 US claimed
US-5808112-A Preparation of cis-4-O-protected-2-cyclopentenol derivatives HOECHST MARION ROUSSEL INC. (US) 1998-09-15 US disclosed
US-5728899-A Preparation of cis-4-O-protected-2-cyclopentenol derivatives HOECHST MARION ROUSSEL INC. (US) 1998-03-17 US disclosed
EP-0817764-A1 PREPARATION OF CIS-4-O-PROTECTED-2-CYCLOPENTENOL DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-01-14 EP disclosed
WO-1996030320-A1 PREPARATION OF CIS-4-O-PROTECTED-2-CYCLOPENTENOL DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1996-10-03 WO disclosed