Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | TAOK3 | Q9H2K8 | 5/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990805 | 0.82 | MTNR1A (0.52) | HTT | |
| SCHEMBL8573856 | 0.82 | MTNR1A (0.52) | HTT | |
| SCHEMBL11924853 | 0.81 | CTSD (0.51) | HTTCTSDBACE1ALDH1A1KMT2A | |
| SCHEMBL10289743 | 0.80 | CTSD (0.49) | HTTCTSDBACE1ALDH1A1KMT2A | |
| SCHEMBL10289744 | 0.78 | BACE1 (0.50) | HTTCTSDBACE1ALDH1A1KMT2A | |
| SCHEMBL8312130 | 0.76 | CTSD (0.47) | CTSDBACE1OPRK1 | |
| SCHEMBL8576126 | 0.75 | MTNR1A (0.52) | — | |
| SCHEMBL8277766 | 0.75 | BACE1 (0.46) | HTTCTSDBACE1ALDH1A1OPRK1 | |
| SCHEMBL8573593 | 0.74 | MTNR1A (0.51) | HTT | |
| SCHEMBL8573589 | 0.74 | MTNR1A (0.51) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |