Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 10/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077431 | 0.96 | HTR4 (0.50) | HTR4HTR7CHRM2ADRA2BHRH2 | |
| SCHEMBL8575502 | 0.91 | HTR4 (0.53) | HTR4HTR7CHRM2ADRA2BHRH2 | |
| SCHEMBL8520377 | 0.88 | HTR4 (0.49) | HTR4HTR7CHRM2ADRA2BHRH2 | |
| SCHEMBL8521031 | 0.79 | HTR4 (0.46) | HTR4HTR7KCNH2 | |
| SCHEMBL8574546 | 0.76 | HTR4 (0.46) | HTR4HTR7CHRM2ADRA2BHRH1 | |
| SCHEMBL8566824 | 0.73 | HTR4 (0.47) | HTR4HTR7CHRM2ADRA2BHRH1 | |
| SCHEMBL8575510 | 0.71 | HTR2A (0.41) | HTR4HTR2AHTR3A | |
| SCHEMBL8575716 | 0.70 | HTR2A (0.38) | HTR4HTR2A | |
| SCHEMBL1077434 | 0.68 | HTR2A (0.39) | HTR4HTR2A | |
| SCHEMBL7449849 | 0.68 | KDM4E (0.53) | HTR4HTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998409-A | GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-12-07 | — | — | US | disclosed |