Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077434 | 0.96 | HTR2A (0.39) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL8575510 | 0.89 | HTR2A (0.41) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL8520380 | 0.81 | HTR2A (0.39) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL8521038 | 0.79 | HTR2A (0.41) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL8574553 | 0.77 | HTR2A (0.39) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL8575712 | 0.70 | HTR4 (0.47) | HTR2AHTR4 | |
| SCHEMBL8566830 | 0.69 | HTR2A (0.39) | HTR2AHTR2CHTR4CNR2 | |
| SCHEMBL1077431 | 0.68 | HTR4 (0.50) | HTR2AHTR4 | |
| SCHEMBL8575502 | 0.67 | HTR4 (0.53) | HTR2AHTR4 | |
| SCHEMBL8521031 | 0.61 | HTR4 (0.46) | HTR4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998409-A | GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-12-07 | — | — | US | disclosed |