SCHEMBL8575787

SCHEMBL8575787

O=C1CCCN1C1CC(Nc2ccc(F)c(Cl)c2)CC[N]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.40
MEN1 O00255 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.38
ALDH1A1 P00352 3/20 0.37
MAPT P10636 2/20 0.37
EGFR P00533 1/20 0.36
POLB P06746 1/20 0.36
USP2 O75604 1/20 0.36
HSP90AA1 P07900 1/20 0.36
GAA P10253 1/20 0.36
PKM P14618 1/20 0.36
HPGD P15428 1/20 0.36
TRPA1 O75762 1/20 0.35
MALT1 Q9UDY8 1/20 0.35
ATM Q13315 1/20 0.35
AADAT Q8N5Z0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8577371 0.83 MAPKAPK2 (0.38) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8574961 0.82 MAPT (0.41) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8575750 0.81 MAPT (0.41) KMT2AMEN1ALDH1A1MAPTEGFR
SCHEMBL8574967 0.79 ALDH1A1 (0.38) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8577103 0.78 KMT2A (0.40) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8573986 0.78 LMNA (0.45) KMT2AMEN1CYP3A4ALDH1A1EGFR
SCHEMBL8573924 0.78 CDK2 (0.42) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8574333 0.78 EGFR (0.41) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8576088 0.78 MAPKAPK2 (0.41) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT
SCHEMBL8577384 0.77 MALT1 (0.37) KMT2AMEN1SMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5821240-A ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS DR. KARL THOMAE GMBH (DE) 1998-10-13 US disclosed