Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9183121 | 0.77 | TUBB4A (0.45) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2779051 | 0.77 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL5324227 | 0.77 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL11427405 | 0.77 | PDE4A (0.64) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL8575969 | 0.76 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL6587870 | 0.75 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL7362170 | 0.75 | TUBB4A (0.43) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7362175 | 0.75 | TUBB4A (0.43) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364010 | 0.74 | PDE4B (0.48) | PDE4APDE4DPDE4BPDE4CMAPK1 | |
| SCHEMBL7913434 | 0.74 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117241803-A | Purine nucleosides, intermediates and methods of making the same | 阿斯特罗赛特制药公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-110003212-B | A3 adenosine receptor agonists | 美国卫生和人力服务部 | 2022-12-06 | — | — | CN | disclosed |
| US-5849774-A | Treatment of sepsis-induced acute renal failure | UNIVERSITY OF PITTSBURGH (US) | 1998-12-15 | — | — | US | disclosed |