Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 16/20 | 0.87 |
| ▸ | EDNRA | P25101 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576085 | 0.93 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8578545 | 0.92 | EDNRB (0.75) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8798300 | 0.90 | EDNRB (0.71) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8577097 | 0.88 | EDNRB (0.84) | EDNRBEDNRA | |
| SCHEMBL8575962 | 0.88 | EDNRB (0.81) | EDNRBEDNRA | |
| SCHEMBL8799772 | 0.88 | EDNRB (0.68) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8577096 | 0.85 | EDNRB (0.85) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8798950 | 0.83 | EDNRB (0.81) | EDNRBEDNRA | |
| SCHEMBL8578916 | 0.81 | EDNRB (0.72) | EDNRBEDNRAKMT2A | |
| SCHEMBL8799108 | 0.81 | EDNRB (0.77) | EDNRBEDNRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |
| CN-1155539-A | Endothelin receptor antagonists | MERCK PATENT GMBH (DE) | 1997-07-30 | — | — | CN | disclosed |
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |