Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 12/20 | 0.71 |
| ▸ | EDNRA | P25101 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798950 | 0.93 | EDNRB (0.81) | EDNRBEDNRAKDM4EALDH1A1MAPT | |
| SCHEMBL8799772 | 0.93 | EDNRB (0.68) | EDNRBEDNRAMEN1KMT2AKDM4E | |
| SCHEMBL8575979 | 0.90 | EDNRB (0.87) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8798655 | 0.88 | EDNRB (0.67) | EDNRBEDNRAKMT2AKDM4EALDH1A1 | |
| SCHEMBL8578545 | 0.88 | EDNRB (0.75) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8799607 | 0.87 | EDNRB (0.64) | EDNRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL8799108 | 0.86 | EDNRB (0.77) | EDNRBEDNRAMEN1KMT2AKDM4E | |
| SCHEMBL8576085 | 0.83 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8798255 | 0.81 | EDNRB (0.79) | EDNRBEDNRAKDM4EALDH1A1MAPT | |
| SCHEMBL8577096 | 0.81 | EDNRB (0.85) | EDNRBEDNRAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |