Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.68 |
| ▸ | EDNRA | P25101 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799108 | 0.94 | EDNRB (0.77) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8798300 | 0.93 | EDNRB (0.71) | EDNRBEDNRAMEN1KMT2APOLB | |
| SCHEMBL8578545 | 0.89 | EDNRB (0.75) | EDNRBEDNRAMEN1KMT2APOLB | |
| SCHEMBL8798090 | 0.88 | EDNRB (0.64) | EDNRBEDNRAKMT2AALDH1A1MAPT | |
| SCHEMBL8799661 | 0.88 | EDNRB (0.61) | EDNRBEDNRAKMT2AALDH1A1KDM4E | |
| SCHEMBL8575979 | 0.88 | EDNRB (0.87) | EDNRBEDNRAMEN1KMT2A | |
| SCHEMBL8798950 | 0.86 | EDNRB (0.81) | EDNRBEDNRAALDH1A1MAPTKDM4E | |
| SCHEMBL8577096 | 0.82 | EDNRB (0.85) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8576085 | 0.81 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL8798655 | 0.80 | EDNRB (0.67) | EDNRBEDNRAKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |