Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MTTP | P55157 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578876 | 0.89 | HDAC1 (0.34) | LMNAMAPTTSHRNPSR1RAB9A | |
| SCHEMBL8574660 | 0.88 | LMNA (0.38) | LMNAMAPTGAATSHRNPSR1 | |
| SCHEMBL8573351 | 0.82 | MAPT (0.41) | LMNAMAPTNPSR1L3MBTL1RXFP1 | |
| SCHEMBL8577131 | 0.81 | GAA (0.34) | LMNAMAPTGAATSHRNPSR1 | |
| SCHEMBL8717983 | 0.81 | CCR3 (0.43) | LMNAMAPTTSHRNPSR1L3MBTL1 | |
| SCHEMBL8573191 | 0.80 | GAA (0.36) | LMNAMAPTGAATSHRNPSR1 | |
| SCHEMBL8668018 | 0.80 | MAPT (0.39) | LMNAMAPTGAATSHRNPSR1 | |
| SCHEMBL8665515 | 0.80 | CCR3 (0.41) | LMNAMAPTNPSR1L3MBTL1 | |
| SCHEMBL8482395 | 0.79 | MAPT (0.38) | LMNAMAPTGAATSHRNPSR1 | |
| SCHEMBL8712537 | 0.79 | CCR3 (0.43) | LMNAMAPTNPSR1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760246-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 1998-06-02 | — | — | US | disclosed |
| US-H1729-H | Method for preparing compounds employing solid phase synthesis and novel linker-resin | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |