Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4155331 | 0.82 | MAOB (0.48) | MAOBCA1CA2ARG2TSHR | |
| SCHEMBL3295095 | 0.82 | MAOB (0.48) | MAOBCA1CA2ARG2TSHR | |
| SCHEMBL8174260 | 0.77 | MAOB (0.48) | MAOBCA1CA2ARG2TRPA1 | |
| SCHEMBL10755711 | 0.76 | MAOB (0.46) | MAOBCA1CA2ARG2TSHR | |
| SCHEMBL8666884 | 0.74 | CYP1A2 (0.47) | MAOBCA1CA2ARG2CYP1A2 | |
| SCHEMBL5347335 | 0.74 | MAOB (0.44) | MAOBCA1CA2ARG2TSHR | |
| SCHEMBL3295725 | 0.74 | TRPA1 (0.46) | MAOBCA1CA2ARG2TRPA1 | |
| SCHEMBL1289345 | 0.71 | MAOB (0.52) | MAOBCA1CA2ARG2CALM1 | |
| SCHEMBL11098509 | 0.71 | SIGMAR1 (0.50) | MAOBTRPA1EPHX1 | |
| SCHEMBL5680524 | 0.71 | MAOB (0.46) | MAOBTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776933-A | Method of inhibiting protease | E. R. SQUIBB & SONS, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5760036-A | ENZYME INHIBITORS OF RETROVIRAL PROTEASE FOR PREVENTION OF AIDS | E. R. SQUIBB & SONS, INC. (US) | 1998-06-02 | — | — | US | disclosed |