SCHEMBL8577398

SCHEMBL8577398

COc1cc2c(c(O)c1O)C(=O)C(c1ccccc1)(c1cccc(Cl)c1)CO2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.38
KDM4E B2RXH2 1/20 0.38
BACE1 P56817 1/20 0.36
SCN9A Q15858 1/20 0.35
MAOB P27338 2/20 0.34
ABCB1 P08183 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.34
MAPT P10636 2/20 0.34
TP53 P04637 1/20 0.34
MEN1 O00255 2/20 0.33
POLB P06746 2/20 0.33
KMT2A Q03164 2/20 0.33
STK10 O94804 1/20 0.33
CLK2 P49760 1/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
STK33 Q9BYT3 1/20 0.33
SLK Q9H2G2 1/20 0.33
CLK4 Q9HAZ1 1/20 0.33
TLK1 Q9UKI8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8574170 0.92 GAA (0.39) GAAKDM4EBACE1SCN9AABCB1
SCHEMBL8576216 0.88 GAA (0.38) GAAKDM4EBACE1ABCB1ABCG2
SCHEMBL8572760 0.86 PLK1 (0.37) BACE1HCAR3HCAR2CHRNA1CHRNB1
SCHEMBL8575371 0.84 HTR6 (0.42) KDM4EBACE1MAOBABCG2MAPT
SCHEMBL8577569 0.83 ABCG2 (0.42) GAAKDM4EBACE1ABCB1ABCG2
SCHEMBL8577389 0.80 GLRA3 (0.34) MAPTTP53MEN1KMT2AHCAR3
SCHEMBL8577388 0.80 GAA (0.39) GAAKDM4EBACE1ABCB1ABCG2
SCHEMBL8572826 0.79 CYP19A1 (0.37) MAOBMAPTMEN1KMT2AHCAR3
SCHEMBL8574474 0.73 PLK1 (0.37) GAAHCAR3HCAR2CHRNA1CHRNB1
SCHEMBL8575417 0.72 RIPK1 (0.41) GAAKDM4ESCN9AABCB1ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998017662-A1 PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE NOVARTIS AG (CH) 1998-04-30 WO claimed
WO-1998017662-A1 PHENYL-SUBSTITUTED BICYCLIC HETEROCYCLYL DERIVATIVES AND THEIR USE NOVARTIS AG (CH) 1998-04-30 WO disclosed