Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | ICMT | O60725 | 4/20 | 0.51 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.47 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11400833 | 0.80 | KDM4E (0.63) | HSD17B10KDM4ECNR2 | |
| SCHEMBL15747729 | 0.79 | CDC25A (0.90) | CDC25AMCL1ICMTHSD17B10KDM4E | |
| SCHEMBL9756422 | 0.77 | CDC25A (0.57) | CDC25AMCL1ICMTHSD17B10KDM4E | |
| SCHEMBL4222752 | 0.77 | AKR1C3 (0.56) | HSD17B10KDM4EAKR1C3AKR1C2AKR1C4 | |
| SCHEMBL2429439 | 0.76 | CDC25A (0.97) | CDC25AMCL1ICMTHSD17B10KDM4E | |
| SCHEMBL10727937 | 0.75 | DYRK1A (0.54) | MCL1CNR2TBXAS1 | |
| SCHEMBL8271864 | 0.75 | HTR6 (0.62) | SSTR5CNR2 | |
| SCHEMBL15747697 | 0.74 | CDC25A (1.00) | CDC25AMCL1ICMTHSD17B10KDM4E | |
| SCHEMBL9700510 | 0.74 | CDC25A (1.00) | CDC25AMCL1ICMTHSD17B10KDM4E | |
| SCHEMBL2685182 | 0.74 | MTNR1A (0.63) | HSD17B10KDM4EAKR1C3AKR1C2AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721347-A | Esters and amides of substituted pyrrole acetic acids | CELL PATHWAYS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0485157-A2 | Esters and amides of substituted pyrrole acetic acids | FGN, INC. (US) | 1992-05-13 | — | — | EP | disclosed |