Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423697 | 0.83 | PTGS2 (0.54) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL15658049 | 0.81 | PTGS2 (0.66) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL11553568 | 0.81 | PTGS2 (0.65) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL6102634 | 0.80 | PTGS2 (0.43) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL6458883 | 0.80 | PTGS2 (0.65) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL10909068 | 0.80 | LMNA (0.59) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8430489 | 0.80 | PTGS2 (0.67) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL11832986 | 0.79 | PTGS2 (0.63) | LMNACYP1A2CYP2D6CYP2C9HIF1A | |
| SCHEMBL6423750 | 0.79 | AKR1C3 (0.53) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL6425916 | 0.79 | PTGS2 (0.61) | NPSR1PTGS2AKR1C3AKR1C2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721347-A | Esters and amides of substituted pyrrole acetic acids | CELL PATHWAYS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0485157-A2 | Esters and amides of substituted pyrrole acetic acids | FGN, INC. (US) | 1992-05-13 | — | — | EP | disclosed |