SCHEMBL8580324

SCHEMBL8580324

O=C(O)CCCc1ccn2ccccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TBXAS1 P24557 1/20 0.52
HDAC3 O15379 1/20 0.49
MAPK1 P28482 1/20 0.49
ADRA1A P35348 1/20 0.49
HDAC4 P56524 1/20 0.49
SLC6A3 Q01959 1/20 0.49
HDAC1 Q13547 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HDAC9 Q9UKV0 1/20 0.49
HDAC5 Q9UQL6 1/20 0.49
FABP4 P15090 3/20 0.45
FABP5 Q01469 3/20 0.45
EGFR P00533 1/20 0.43
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15172916 0.94 TBXAS1 (0.57) TBXAS1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL10767518 0.90 KEAP1 (0.46) TBXAS1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL3230868 0.80 AKR1B1 (0.47) EGFRMEN1KMT2AALDH1A1APEX1
SCHEMBL2878880 0.74 HDAC3 (0.68) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL31512109 0.74 HDAC3 (0.68) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL17537572 0.71 HDAC3 (0.63) HDAC3MAPK1ADRA1AHDAC4SLC6A3
SCHEMBL22826566 0.69 MAPT (0.67) TBXAS1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL10976272 0.69 TBXAS1 (1.00) TBXAS1MAPTRXFP1F13A1
SCHEMBL31305289 0.69 FABP4 (0.54) TBXAS1HDAC3MAPK1ADRA1AHDAC4
SCHEMBL28991551 0.69 KDM4E (0.67) HDAC3HDAC1SMN1; SMN2HDAC6FABP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP disclosed
EP-0792371-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1998-12-30 EP disclosed
EP-0792371-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-09-03 EP disclosed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP disclosed
US-5543417-A 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent MERCK & CO., INC. (US) 1996-08-06 US disclosed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO disclosed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO disclosed