SCHEMBL8580685

SCHEMBL8580685

Oc1ccc(C(Cl)C(Cl)(Cl)Cl)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 12/20 0.65
ESR2 Q92731 11/20 0.65
PDCD1 Q15116 1/20 0.46
CD274 Q9NZQ7 1/20 0.46
ALOX15 P16050 3/20 0.42
LMNA P02545 3/20 0.42
HIF1A Q16665 3/20 0.42
CYP3A4 P08684 2/20 0.42
MAPT P10636 2/20 0.42
NFKB1 P19838 2/20 0.42
KDM4E B2RXH2 2/20 0.42
HPGD P15428 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
CA12 O43570 1/20 0.42
GMNN O75496 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA3 P07451 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9073727 0.81 ESR1 (0.50) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL2176520 0.80 ESR1 (0.62) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL11587500 0.80 ESR1 (0.48) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL44658 0.79 ESR1 (1.00) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL28501352 0.79 ESR1 (0.65) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL7120983 0.77 ESR1 (0.62) ESR1ESR2PDCD1CD274ALOX15
Hydrochloric Acid SCHEMBL11317436 0.77 ESR1 (0.95) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL9250303 0.76 TSHR (0.64) ESR1ESR2LMNAHIF1ACYP3A4
SCHEMBL4593276 0.75 ESR1 (0.60) ESR1ESR2PDCD1CD274ALOX15
SCHEMBL21380596 0.75 ESR1 (0.52) ESR1ESR2PDCD1CD274ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59140222-A None JP disclosed
US-5719256-A CONDENSING CARBOXYL GROUP CONTAINING COMPOUND AND ACTIVE HYDROGEN CONTAINING COMPOUND IN PRESENCE OF HALOIMINIUM SALT AS POLYMERIZATION CATALYST MITSU TOATSU CHEMICALS, INC. (JP) 1998-02-17 US disclosed
EP-0362872-B1 Polybutylene terephthalate moulding compositions with an improved flowability SUMITOMO WIRING SYSTEMS (JP) 1993-12-22 EP disclosed
CN-1020913-C Polybutylene terephthalate moulding composition with improved flowability SUMITOMO WIRING SYSTEMS (JP) 1993-05-26 CN disclosed
EP-0259692-B1 METHOD FOR MAKING CONSOLIDATED FIBRE FLEECES, AND CONSOLIDATED FIBRE FLEECES RHONE-POULENC RHODIA AKTIENGESELLSCHAFT (DE) 1991-10-30 EP disclosed
US-5039727-A Blends of polyesters having varying viscosities, release agents; molding materials SUMITOMO WIRING SYSTEMS, LTD. (JP) 1991-08-13 US disclosed
EP-0212862-B1 POLYMERISATION PROCESS FOR POLYESTER MITSUBISHI RAYON CO., LTD. (JP) 1991-03-20 EP disclosed
CN-1043514-A Improve the moulding compound of mobile polybutylene terephthalate SUMITOMO WIRING SYSTEMS (JP) 1990-07-04 CN disclosed
EP-0362872-A2 Polybutylene terephthalate moulding compositions with an improved flowability SUMITOMO WIRING SYSTEMS, LTD. (JP) 1990-04-11 EP disclosed
US-4818594-A Consolidated nonwoven fabrics and process for producing them RHODIA AG (DE) 1989-04-04 US disclosed
EP-0259692-A2 Method for making consolidated fibre fleeces, and consolidated fibre fleeces RHONE-POULENC RHODIA AKTIENGESELLSCHAFT (DE) 1988-03-16 EP disclosed
US-4687811-A USING AS DISPERSION STABILIZER A GRAFT POLYMER OF POLYSILOXANE AND ACRYLATED RESINS MITSUBISHI RAYON CO., LTD. (JP) 1987-08-18 US disclosed
EP-0212862-A1 Polymerisation process for polyester MITSUBISHI RAYON CO., LTD. (JP) 1987-03-04 EP disclosed
JP-S59140222-A AROMATIC POLYESTER OF HIGH TERMINAL-CARBOXYL GROUP CONTENT AND ITS PRODUCTION TEIJIN LTD 1984-08-11 JP disclosed
US-4436896-A HOT MELT ADHESIVES DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1984-03-13 US disclosed
US-4230762-A SYNTHETIC NON-WOVEN FABRIC, WOVEN OR KNIT FABRIC LAYER MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) 1980-10-28 US disclosed
US-4072779-A LAMINATION WITH POLYVINYL BUTYRAL E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-02-07 US disclosed
US-3933713-A Method for preparing aromatic polyesters SOKOLOV LEV BORISOVICH 1976-01-20 US disclosed